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The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

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Audible Audiobook

Listening Length: 9 hours and 43 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: HighBridge, a division of Recorded Books

Audible.com Release Date: May 14, 2013

Whispersync for Voice: Ready

Language: English, English

ASIN: B00C7DXYHY

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Today's news reporting and book literature is slowly reflecting the emerging cancer research and treatment landscape - targeted, specific and narrowly effective. The first book I read that described this new cancer universe was "Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer."In "Philadelphia Chromosome," author Jessica Wapner describes how chronic myeloid leukemia (CML) went from a painful and fairly rapid death sentence to a largely chronic condition managed through Gleevec, an orally-administered drug that targets cancer at its genetic level.Wapner writes a gripping, yet restrained, tale that recognizes both the promise and limits of this new approach to the age-old problem of cancer. She profiles Brian Drucker, the doctor who championed the development of the drug, as saying, "if I told you I could give you a pill that was going to put your cancer in remission with no side effects, would you believe it?"For the 5,000 patients diagnosed each year with CML in the U.S., the answer happily is, "yes." And given the devastating side effects and oftentimes futile results from the mainline cytotoxic cancer treatments, the answer desperately needs to be "yes." Wisely, though, as tempting as it is to extrapolate the miraculous success of Gleevec to larger arenas in which the cancer fight is still taking place, Wapner doesn't overreach.For this reason, besides the outstanding reporting that narrates the personalities, forces and science that unraveled this complex disease and discovered its one-of-a-kind cure, Wapner's book gets 5 stars.

This book was well written and understandable to a non-scientist, such as myself. That is not to say, however, that I wasn't sometimes confused about how all the different people whose discoveries came together to lead to the discovery of Gleevec fit together. The author jumps back and forth a bit and there were a lot of names and patients to keep track of, and I had to stop and try to recall who we were talking about. And I'm not a biochemist and since my chemistry in high school days are long gone, I had to look up a bunch on wikipedia to refresh my recollection of cellular processes. Although, I'm not saying that this book isn't well written. Far from it. The author uses good analogies to help the reader understand the cellular processes. Without that help, I would have been lost.The Philadelphia chromosome has had an unfortunate effect on my family. I have had a 3rd cousin die from leukemia who had received a bone marrow transplant, a first cousin die from cml with the philadelphia chromosome, and a nephew with ALL with the philadelphia chromosome survive because he got to take Gleevec. My first cousin with CML went into blast stage a short couple of months after Gleevec was featured on the news and he was unable to get the medicine that would have saved his life. So, this topic is very real and personal one to me and this book helped me to understand the process of the disease and the miracle of the discovery this book speaks of. I just wish the 3 years of stalling on the beginning of trials had not existed, because those were the 3 years that my cousin could have got on the trial and lived. He left four children and a wife. He was the sole support and comfort of his family. I miss him.

This really was a great book for me to read. I loved doing research in med school. But I've been teaching for several years premed and nursing students. I had heard about the Philadelphia Chromosome in all of my textbooks, but they don't say as much about it as they could have...so I absolutely needed to read this book. I don't think people realize the amount of time and work it takes from having an inkling about something going strange in the human body, and taking it to a conclusion that will possibly help people. USually it takes decades and many, many groups and people involved in figuring several different pathways to the same ending to finally decode where the problem lies.Chronic myelogenous leukemia is one of the nastier cancers out there. I knew people who got this and died from it. There was almost nothing to treat it. It was like pancreatic cancer is now...we would kind of shake our heads, and cry...because it was a death sentence. But there was someone who really observed what was happening between two chromosomes. Usually when we copy chromosomes they don't have a problem, but every once in a while, a chromosome will delete something or invert something...and what gets made by that chromosome (DNA goes to RNA goes to proteins) gets made wrong. In this case, it was an enzyme...and that enzyme led towards cancer. CML is usually an older person's disease. Why? Because as we get older, our ability to repair mistakes in our cells get significantly less.This book follows the many great people and corporations who worked on this problem, in order to find something that would heal this disease. I'm impressed with the story, impressed with the people. And I was impressed with the wriiting of the author. A much needed to book for people who know nothing about doing research. REsearchers do not get the fame they should ever...but they should!Having said all this about this being a great book...I didn't like the ending of the book because it sounded like a shill for the pharmaceutical companies. Most research is done by universities, and the pharmaceutical companies usually get the end of the research and make money off of it. I do admit the corporations here did a lot more than many of them do...but it really makes me wonder if this book was paid for originally by the companies pushing this particular drug. It saves lives, but to me this smacked of a book that was subsidized to make Big Pharma look good, when currently they do way too many things wrong.

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Ebook Download Principles of Statistics for Engineers and Scientists

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Principles of Statistics for Engineers and Scientists

Ebook Download Principles of Statistics for Engineers and Scientists

Schedule Principles Of Statistics For Engineers And Scientists is one of the valuable worth that will make you always abundant. It will certainly not indicate as abundant as the cash provide you. When some individuals have absence to face the life, individuals with numerous publications occasionally will certainly be smarter in doing the life. Why should be publication Principles Of Statistics For Engineers And Scientists It is really not suggested that publication Principles Of Statistics For Engineers And Scientists will certainly provide you power to get to every little thing. The book is to read and what we indicated is the publication that is read. You can additionally see just how guide entitles Principles Of Statistics For Engineers And Scientists and also varieties of publication collections are offering right here.

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About the Author

William Navidi received a B.A. in mathematics from New College, an M.A in mathematics from Michigan State University, and a Ph.D. in statistics from the University of California at Berkeley. Dr. Navidi is a professor of applied mathematics and statistics at the Colorado School of Mines in Golden, Colorado. He began his teaching career at the County College of Morris in Dover, New Jersey. He has taught mathematics and statistics at all levels, from developmental through the graduate level. Dr. Navidi has written two engineering statistics textbooks for McGraw-Hill and has authored more than 50 research papers, both in statistical theory and in a wide variety of applications, including computer networks, epidemiology, molecular biology, chemical engineering, and geophysics.

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Product details

Hardcover: 608 pages

Publisher: McGraw-Hill Education; 1 edition (January 26, 2009)

Language: English

ISBN-10: 0077289315

ISBN-13: 978-0077289317

Product Dimensions:

7.8 x 1.1 x 9.4 inches

Shipping Weight: 2.4 pounds (View shipping rates and policies)

Average Customer Review:

4.2 out of 5 stars

80 customer reviews

Amazon Best Sellers Rank:

#138,951 in Books (See Top 100 in Books)

The book explains concepts fairly well, and has decent example problems. However, I have an issue with it especially because it is a statistics book, where there are very minor equation shifts for very similar types of problems--it would be really nice if the book included a sort of equation sheet at the end of each chapter, stating the type of problem that each equation is useful for. Like after the chapter on hypothesis tests (which really blend together), it would be great if there were something like "Two-tailed hypothesis test, large sample: this equation; Chi-squared hypothesis test: this equation," etc. It had little boxes where there were important equations, but a summary sheet would have been incredibly helpful.

My students, on the whole like statistics. I think the text plays a key part in this. The problems are realistic and not over repetitive. I use R as my programming language for the course, with no difficulty.

Awesome book. Great examples and easy to follow hw problems.

Reading though the text book isn't too horrible, the book generally makes sense. My two main vices with this book is that it is sometimes difficult to understand what a specific symbol represents or where they got the value for it. I also don't like how you have chapters 1-10, the tables, answers to odd # questions then the index. It makes the tables incredibly difficult to find (except for the ones on the front and back cover. I recommend putting tabs into your own copy so you can find the tables easier.

The textbook served the purpose well for my stats class that it was required for. The book is pretty well laid out and has good summary boxes after each section. The one thing I would warn is that the same professor that wrote this book also wrote "Principles of Statistics for Engineers and Scientists", which is not the same. If you are getting this as a required textbook for a course, make sure you are getting the right textbook!

This book was alright for learning engineering statistics, but it wasn't as easy to follow and 'dumbed down' as I hoped it would be. It was a very challenging class and I wish the text book had done a little better job of explaining.

This is a wonderful, clear book for an introduction to statistics. It has plenty of concrete examples and it's well paced and laid out. I've used it extensively for my Ph.D. research in space physics. One word of caution: there's not really any discussion about time-series data, so if you're dealing with dependent samples or an autoregressive process, this book will only get you half way there.

This book is clear and concise. It's also very easy to understand and follow. I would've given 5 stars, but there was a little tear in the back cover.

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Get Free Ebook Lost and Found In Spain: Tales of An Ambassador's Wife, by Susan Lewis Solomont

This is exactly what you could extract from this book. By soft data types, you can be offered to review it in the gadget when you are in your way home in cars and truck or bus or perhaps train. It is your time also to review it when you are remaining in a waiting checklist. And also how you can check out Lost And Found In Spain: Tales Of An Ambassador's Wife, By Susan Lewis Solomont in your home can utilize the moment before sleeping and functioning.

Lost and Found In Spain: Tales of An Ambassador's Wife, by Susan Lewis Solomont

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Review

“In these pages, Susan Solomont has shared an exhilarating story of the challenges and the special joys of representing America abroad, which will inspire, educate and delight. This powerful portrait of perseverance and courage is a great gift as we navigate new changes and challenges in our life’s journey.” —Nancy Pelosi, Speaker of the House“Susan shows us with her memories of traveling around my homeland the importance of cultural and culinary diplomacy—that one of the best ways to understand and connect with a country and people is through their food.” —José Andrés, Chef“In Lost and Found in Spain, Susan Solomont makes the patriotic expatriate life her own and reminds us that an Ambassadorship is a family calling.” —John Kerry, 68th US Secretary of State"A vivid, honest, and loving account of life behind the scenes in one of the most coveted and dazzling institutions that represents the United States. That Susan and Alan Solomont quickly got labeled 'Team Solomont' among the diplomatic circles in town is a testimony to Susan's brilliance, easy charm, and delightful wit, which find ample expression in her book." —H.E. Ana de Palacio, Former Minister of Foreign Affairs of Spain"In Lost and Found in Spain, Susan Lewis Solomont provides the rare gift of revealing the world of diplomacy. She takes us behind the walls of the US Embassy in Spain and we get a portrayal of life through the lens of an entrepreneurial woman. She offers an in-depth tour into the world of protocol and the role that spouses make for themselves in this mysterious yet intriguing world. And did I mention the food? That alone is worth the ride—but there's far more in this fascinating book." —Randy Susan Meyers, Author

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About the Author

From 2008 to 2012, Susan Lewis Solomont served alongside her husband, Alan Solomont, in Madrid, Spain, where he was appointed as U.S. Ambassador to Spain and Andorra under President Barack Obama. She was named International Woman of the Year by FEDEPE, the leading organization for Spanish women executives and directors. She holds a Bachelor of Science degree from Cornell University and a master’s degree in education from Tufts University.

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Product details

Paperback: 276 pages

Publisher: Disruption Books; None edition (March 26, 2019)

Language: English

ISBN-10: 1633310302

ISBN-13: 978-1633310308

Product Dimensions:

5.5 x 0.5 x 8.5 inches

Shipping Weight: 9.9 ounces (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

6 customer reviews

Amazon Best Sellers Rank:

#75,007 in Books (See Top 100 in Books)

I bought this book for my mom who wanted to read it before she met the author and here's her review, " Before reading the book, I thought it would be all about what an embassy and ambassadorship are all about and the important role of diplomacy. It was that, but so much more. The author shared her feelings so candidly about the struggles she went through to find a place for herself in a different cultural environment and in a place where as an ambassador’s wife she had no official role. I was inspired with how determined she was determined to make a meaningful contribution and chart a new course in a very deliberate, authentic , and proactive way. This book is a “must read” for all of us who want to make a difference in the world.

I have read many books about people who have been in Spain, from Ambassadors to members of our Armed Forces, without a doubt, this is the best book I have read, very detailed and with moving and personal stories. Thank you Susan for such a wonderful book, will there be a second part?

Susan offers a window into daily life along with the development of inner thoughts,doubts and yearnings as she served our country as an ambassador’s wife. Touching, intimate and heartfelt. Very engaging !

Really special and personal journey of the author's experience as "the wife" of the Ambassador to Spain. Could not put this down! This book brings Spain to life on paper, and an inspiring story for women of all ages!

A wonderful travelogue but even more importantly, a story of self-awareness, growth and empowerment. An easy and delightful read!

This is a beautiful story of self reflection, finding your path, and grabbing a Spanish bull by the horns when life throws you a serious curveball.This book has got it all - wonderful people, history, travel tips, and Grateful Dead references.Thank you for sharing your story Susan!

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Free PDF If I Can't Have You: Susan Powell, Her Mysterious Disappearance, and the Murder of Her Children, by Gregg Olsen Rebecca Morris

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If I Can't Have You: Susan Powell, Her Mysterious Disappearance, and the Murder of Her Children, by Gregg Olsen Rebecca Morris

Free PDF If I Can't Have You: Susan Powell, Her Mysterious Disappearance, and the Murder of Her Children, by Gregg Olsen Rebecca Morris

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Review

“Olsen's [writing] is both gossipy and sympathetic, searing and brilliant. . . . A must read for true crime aficionados and students of abnormal psychology! I read until 3 a.m.!” ―Ann Rule on If Loving You is Wrong“Gregg Olsen is one of this country's favorite true crime writers…Olsen takes readers behind the scenes of this fascinating case.” ―Tucson Citizen on A Twisted Faith“As good as it gets.” ―Lee Child on A Wicked Snow“A rapid-fire page-turner.” ―Seattle Times on A Twisted Faith“A disturbing portrait of a community undone by its appealing young pastor…. An unsettling story of a man who committed murdered and then used his charm and his power as a man of God to exploit his congregants and satisfy his sexual obsession.” ―Publishers Weekly on A Twisted Faith“Dark, atmospheric, riveting suspense . . . Gregg Olsen is one of the best.” ―Allison Brennan, New York Times bestselling author of Fear No Evil on A Cold Dark Place

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About the Author

A New York Times and Wall Street Journal bestselling author, gregg olsen has written nine nonfiction books, ten novels, a novella, and has contributed a short story to a collection edited by Lee Child. rebecca morris is the New York Times bestselling author of Bodies of Evidence (with Gregg Olsen) and Ted and Ann. She is an award-winning reporter and has worked in journalism in New York City; Portland, Oregon; and Seattle, Washington.

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Product details

Mass Market Paperback: 320 pages

Publisher: St. Martin's True Crime; Reissue edition (May 5, 2015)

Language: English

ISBN-10: 9781250066688

ISBN-13: 978-1250066688

ASIN: 1250066689

Product Dimensions:

4.3 x 0.9 x 6.8 inches

Shipping Weight: 5.6 ounces (View shipping rates and policies)

Average Customer Review:

4.5 out of 5 stars

356 customer reviews

Amazon Best Sellers Rank:

#34,464 in Books (See Top 100 in Books)

IF I CAN'T HAVE YOU by Gregg Olsen and Rebecca Morris is the best book of Olsen's that I've read. In addition, it's the best book on the true crime case of Susan Powell on the market. As much as I love Ann Rule' s books, IF I CAN'T HAVE YOU surpasses the book which includes her version of this case by far.This is due to the authors having in depth access to the case through a connection with Susan's parents, Chuck and Judy Cox. Thereby an entire other dimension is given to this story's rendering and details.Having followed this case from the first day Susan was reported missing, tragedy is heaped upon tragedy in the storyline's unfolding. Olsen and Morris do a superb job of capturing the sadness, horror, and dismay of the circumstances surrounding the disappearance of Susan and the deaths of her two young sons, Braden and Charlie.One of the most tragic aspects of this case is that the Coxes made repeated attempts to warn both law enforcement and CPS that Susan's husband, Josh, (also the main suspect in her disappearance) could prove to be a danger to the children. It was a warning that went unheeded to their horrifying detriment.The moral of this part of the story is never, ever back a narcissist into a corner, because he will win at all costs. And Josh Powell proved to be a diagnosed narcissist through the child custody court case. He was totally underestimated except by those who were closest to Susan and her sons.Ultimately it comes to be known after her disappearance that Susan was in way over her head with the toxic, dysfunctional and sexually perverted Powell family system. Although she trusted her instincts to a degree, she was much to naive a young woman to recognize the depth of depravity surrounding her. This, by far, is one of the most horrific true crime cases I've ever read about.

As I am Susan Powells sister I read the book to to check out the facts of my sister's case. I was impressed with how accurate and well written the information is Gregg and Rebecca did an excellent job telling my family's story. This is the best book I have read so far about my sister. I encourage anyone and everyone to read this book. Although this is a sad story, it is a well written account of my family's struggle.

Gripping story which is very well written by Olsen. Before reading this I had only heard the headlines about this case. The book brings you into the community and the families and all the heartache.What is so shocking is the behavior of the Powell family. Maybe it's not so shocking as shameful of this dysfunctional evil family. They would not cooperate with police, they circled their wagons and kept quiet about what they knew but used the internet to smear the reputation of the missing woman. They cared nothing about Susan or where she was and only wanted to protect their brother Josh. The creepy narcissistic perverted father of Josh Powell, Steve Powell who was convicted on voyeurism for taking pictures of his young neighbors in the bathroom, is still refusing to say what he knows. The brother who committed suicide one year after Josh's murder suicide rampage, probably helped dispose of the body and he died keeping his secrets. Maybe if the Powells had cooperated, the children would not have been murdered as Josh would have been arrested before that horrible day. Some reviewers speak ill of the social worker who took the children to visit their father that fateful day, but she was doing what the court mandated. The judge and legal system should have listened to the many warnings given by Susan's father and the Cox family attorney.

This is a relatively well-written story about a young wife and mother who goes missing and presumed dead, though her body was never found, and the subsequent murder-suicide of her husband, who was a person of interest, and their two children. There is little doubt, in my mind, that the husband murdered her and was later aided by his brother and possibly his father in the cover-up of his crime.What stands out in this book is the quality of the police work, which I thought left a lot to be desired, and the fact that the children were left in the care and custody of the suspect, despite the fact that they there were signs that he was not providing a suitable home nor a suitable environment. Moreover, the suspect's father, with whom he was living for a time, had serious sexual issues of a disturbing nature, many centered around the children's mother.It is a sad story all around, and a bit unsatisfying, due to the fact that the reader does not know what exactly happened to this young wife and mother other than she was presumably murdered. It is also quite frustrating to know that the children were kept with their father. The book may have had a different ending, if the court had only done what would have been in the best interest of the children.

'If I Can't Have You' is one of those books in the True Crime genre that cause you to question whether you're reading real life or fiction. The sick part about this case is that with every turn you can only wish it was fiction. Not only was Josh obviously warped, his family/pedo dad was a disgrace. Even worse, due to what police continued to believe was a 'lack of sufficient evidence', a psychopath was able to wipe out his entire family. Holy crap, have I woken up yet?!The only criticism I have is that it seemed repetitive and long winded in parts where it needn't have been. Perhaps it's because I knew how the story would end, but nonetheless, I found this book to be especially dry at times.If you've yet to read about the Powell case, I do recommend 'If I Can't Have You'. I don't know about others, but from Susan's disappearance to the way her poor boys met their end, I was questioning law enforcement's strategy and involvement. It was bad enough that Susan paid with her life... yet a few years later, law enforcement and the justice system allowed her two sons to also die at the hands of their father. Mind blowing... And tragically, too little, too late.

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Product details

Paperback: 1344 pages

Publisher: Tyndale House Publishers, Inc. (September 1, 1998)

Language: English

ISBN-10: 0842333894

ISBN-13: 978-0842333894

Product Dimensions:

6 x 1.5 x 9 inches

Shipping Weight: 2.4 pounds (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

7 customer reviews

Amazon Best Sellers Rank:

#1,189,073 in Books (See Top 100 in Books)

This was sent to my granddaughter and as a result she became a Christian. Easy reading and I have one myself and highly recommend it for new Christians and for those who need a clearer understanding of scriptures.

A Bible that should be given to every Christian teenager who wants an in-dept study to God's Word.

We all love it! And we have recommended to it all of our friends! You should try it!! Thank you!

All was great and arrived promptly :)

I work with the youth at my church and I highly recommend this particular Bible. When they created this Bible they did a good job.This student Bible has incites from one of the leading youth authors and leaders Josh Mc Dowell. His incites are PRICELESS. This Bible has life questions for the youth reader to answer and also true and false questions with the scripture references to help youth understand the scriptures. The New Living Translation is so EASY to READ.I highly recommend this Bible simply because of the incites of Josh McDowell and the easy to understand translation. GOD BLESS YOU ON YOUR JOURNEY.

For years it seems the NIV "The Student Bible" has dominated the landscape of Bibles for students. "The Rock" is-without a doubt-the new standard. The readability of the New Living Translation coupled with the excellent commentary and helps makes this the Bible of choice for my Student Ministry.

I am 15. I've been a Christian for 11 years. I've read my Bible every day of my life, and God never ceases to speak to me, even when I don't understand some of what I'm reading. I picked up The Rock and God totally rocked my world!! I understand EVERYTHING and it's so relevant to me!! I definitely recommend this!!

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Audible Audiobook

Listening Length: 8 hours and 38 minutes

Program Type: Audiobook

Version: Unabridged

Publisher: Audible Studios

Audible.com Release Date: January 14, 2005

Whispersync for Voice: Ready

Language: English, English

ASIN: B0007OB42M

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I'll often buy a premium kindle edition of a book that I could otherwise get for a much cheaper price, to get a well-designed reading experience, paragraphs that look like paragraphs, and perhaps some useful scholarship in introductions and annotations. Generally I'm trying to avoid the kind of type layout where there is a blank line between non-indented paragraphs, which is very common in free editions. Hack-job introductions are also a turn-off.I bought the Harcourt/Harvest kindle edtion of "Orlando", edited by Mark Hussey, about three years ago, and I'm reading it now. It has way too many typos. There are dozens of times when "tl" becomes "d", so "title" becomes "tide", etc. Disappointing in what should be a quality edition. OCR with shoddy QC, perhaps.Others have complained that the footnotes are not tied to the text. That's true, but it doesn't bother me much, since I just finished reading the Penguin Deluxe "Les Miserables", which did the same thing in a physical (non-kindle) book. Avoiding the intrusiveness of a bunch of superscripted endnotes: to me, that's a reasonable design choice.Overall, this kindle edition of "Orlando" isn't really worth paying extra for, so I would recommend rummaging around among the cheaper editions before buying this one.

The most brilliant portrayal of a transsexual experience in modern history. Even when Magnus Hirshfield was publishing his treatise on the transsexual phenomenah, Woolf relates an account of the intracies of gender identity undiscovered by social scientists and biologists. Published in 1928, Orlando has been billed as one of Woolf's best imaginative works however, such criticism was never seen in the light of reality but a surreal depiction of the writer's portrayal of a young man who wakes up one day as a woman, as if in the ordinary course of his life. As Woolf suggests of her character's reaction to the change "Orlando herself showed no surprise at it.(Woolf, 139. Modern transsexuals have explained only recently in their writings, their internal thinking stays the same, only the external body appears different to others. ALthough Woolf's work set the precedent for post modernist literature, infusing elements of fiction into biography, she weaves the internal stuggle of her former lover, Vita Sachville-West's life, together with her own perceptions of gender and sexuality, with an historical account of a young transsexual aristocrat's adventures over the span of centuries. Unlike a biography of her time, the action is secondary to the internal story. This is more of an account of how her lover (and as suggested by this author--Woolf herself), struggles with her own gender identity; a thinking so similar to transsexualism and conflict with a Eurocentric binary gender system. Here, the biographer (narrator) describes: the reaction to Orlando's change of sex, as it may appear in a scientific journal today;"[b]ut in every other respect, Orlando remained preceisely as he had been. The change of sex, though it altered their future, did nothing whatever to alter their identity. (Woolf, 138). Woolf captures the failure of the general public to grasp the concept of gender reassignment when she has the narrator express dismay in the lack of Orlando's reaction where "Orlando was a man till the age of thirty (Similar to our understanding of modern transsexuals who start their transition at middle age) when he became a woman and has remained ever since." (Woolf, 139)'. Woolfe's use of metaphor and foreshadowing is uncanny. The pyrotechnic displays prior to the deep sleep of Orlando depicts change. She puts Orlando on a ship called the 'Enamoured Lady,' and she is suddenly the object of the Captain's and other males' attention and realizes that the sexual fantacies of men creates a dillemma for her as a woman, where she must sheild her own desires as a woman. Woolfe precisely proclaims that '(Orlando) remembered how, as a young man, she had insisted that women must be obedient, chaste, scented, and exquisitely apparelled... (and) "Now I shall have to pay in my own person for those desires ... for women are not (judging by my own short experience of the sex) obedient, chaste, scented, and exquisitely apparelled by nature." Woolfe does not stop at her proclivity to undress Orlando's gender identity but lays bare the confusion of sexual preference. Although a woman herself, Orlando proclaims that "it was still a woman she loved; and if the consciousness of being of the same sex had any effect at all, it was to quicken and deepen those feeling which she had had as a man." (Woolf, 161). Where she gives in to sensual thoughts of a man, the Captain on whose arm she trembles and remembers that she had once been a Duke and Ambassador, "that she, who had been lapped like a lily in folds of paduasoy, had hacked heads off, and lain with loose women amoung treasure sacks in holds of pirate ships..." Woolfe reveals a metaphoric character, the Archduchess Harriet Griselda of Finster-Aarhorn and Scan-op-Boom in the Roumanian territory, seen in chapter three as a woman, and in a later chapter is shown to be a man, the Archduke, who suddently professes his love for her. Woolfe's ability to produce a character like the Arduke Harry who today would fall somewhere on the transgendered scale, is amazing, for a woman in her time. Yet through all its carefully crafted language and delightful parody, the gender message she professes is much the same today as it may have been then, that "Clothes ... change our view of the world and the world's view of us...." Orlando challenges the Eurocentric binary gender construct of the world she lived in. Here, the writer's own indictment of the unrealistic bounds placed on women is evident and transposed by her narrator and Orlando's own expository reflections, "In every human bing a vacillation from one sex to the other takes place, and often it is only that clothes that keep the male or female likeness, while underneath the sex is the very opposite of what it is above." (Woolfe, 189). Here, Woolfe appears to challenge more than the unfairness and imperfections of gender traditions on women. She uses comparaisons of the formalities of being a nieteenth century man and woman to make her point. Additionally, the most introspective journey in Orlando, is of a person who is not questioning her own gender identity, but defining it. Woolfe appears to depict, not confusion, but knowledge by the transsexual main character of her own identity, and chosing to adapt to it by changing the way the world looks at her, by changing sex. It is the world that suffers the confusion. Woolfe makes generalities about other persons hiding their sex in the clothing of the other gender, suggesting there are numerous persons in her era that suffer from some sort of gender dysphoria. After reading Orlando, and comparing it with the writings of transsexual, transgendered and social scientists,Woolfe describes so clearly the struggle a transgendered person experiences, that critics should look more closely at this writing. Woolfe's narrator states: "Of complications and confusions which thus result every one has had experience;" and as though afraid to delve deeper, she leaves this general question to "note only the odd effect it had in the particualr case of Orlando herself." As Woolfe so eloquently portrays the posttranssexual eptiome, "having now worn skirts for a considerable time, a certain change was visible in Orlando, which is to be found even in her face..." and where the narrator wonders, had both the man and woman of Orlando's time.worn the same clothes (in other words, different sexes but same gender) it is possible their outlook may have been the same too." (Woolfe, 188). Yet the most profound statement made in the text reveals Woolfe's secret exposition: "The difference between the sexes is, happily, one of great profundity. Clothes are but a symbol of soemthing hid deep beneath. It was a change in Orlando herself that dicated her choise of a woman's dress and of a woman's sex. And perhaps in this she was only exprssing rather than mor openly than usual---openness indeed was the soul of her nature---(Woolf, 189). Thus, Woolfe explains that Orlando chose to change his sex because he was in fact a woman, a woman's soul in a man's body. This book is highly recommended to all who are ever wonder what it is like for a transsexual to alter his sex, and begin living as the gender opposite of his or her sex. And for those who never wondered, it is a great read, full of insightful commentary on the possibility of a gender continuum and expanding the boundaries of a binary gender system of a phallocentric society.

I admit I went into this novel with some pre conceived thoughts about Orlando. The synopsis on various sites really doesn't do the book justice. I'd read To The Lighthouse prior to this novel and I admit I was somewhat prejudiced.To say I was surprised by Orlando is an understatment. The concept, the style and prose was for this reader an eye opener. Prose that I could fall into and savour.I'm rating it highly because of it's uniqueness and it is a book that you can not be ambivalent about. To me that is what reading is all about.

If you have an interest in witnessing the perfect use of the English language in narrative, anything written by Woolf will do and Orlando is not exception although it is an atypical Woolf work. It is an interesting mix of humor and serious comments on maleness and femaleness, English class history, and insider jokes some of which require a knowledge of Woolf's personal relationships. It helped me to have finished a recent biography of Virginia Woolf to better understand her work generally and especially this one.

The product description does not state the notes in this edition are END NOTES, not foot notes. The text does not indicate at all which terms/etc. are annotated. The notes are listed by page number at the end of the novel. Basically, you need to flip to the back of the book to see if there are any notes for each page. I found the notes themselves helpful but inconvenient to use.The playwright Sarah Ruhl (two-time Pulitzer finalist, 2006 recipient of the MacArthur Fellowship) recently released a stage adaptation of this novel. In her introductory notes, she recommends the Penguin Classics version annotated by Sandra M. Gilbert.

Orlando is a significant story to say the least. It's perhaps one of the most important reflections on gender identity that we have available to us. Just don't buy this version! No page numbers, weird line spacing, random hyphens placed throughout the text; all of these print issues make it really hard to lose yourself in the writing. Spring for a better edition because this isn't worth the $5. Feels like it was pulled from another edition and no further editing was done to the format.

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Book Description

The Book That Should Have Been in the Box

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About the Author

Chris Grover is a veteran of the San Francisco Bay Area advertising and design community, with 25 years experience in print, video, and electronic media. He is the author of Office 2011: The Missing Manual, Google SketchUp: The Missing Manual, Flash CS5.5: The Missing Manual, and Premiere Elements 8: The Missing Manual. When not writing popular technical books, Chris runs Bolinas Road Creative, an agency that helps small businesses promote their products and services.

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Product details

Series: Missing Manuals

Paperback: 848 pages

Publisher: O'Reilly Media; 1 edition (June 29, 2012)

Language: English

ISBN-10: 1449316255

ISBN-13: 978-1449316259

Product Dimensions:

7 x 1.6 x 9.2 inches

Shipping Weight: 2.6 pounds (View shipping rates and policies)

Average Customer Review:

3.9 out of 5 stars

11 customer reviews

Amazon Best Sellers Rank:

#1,807,305 in Books (See Top 100 in Books)

The book goes into great detail and was usually quite helpful. My only complaint is that it is a CS6 book with examples in ActionScript 2.0. CS6 has ActionScript 3.0. Also, some of the screenshots must be of CS5 because they don't always match my screen.

the book is a good reference if you are new to flash, it shows you how to work with flash, I gave it three stars because there isn't much actionscript included and I think that working with flash without actionscript is using about 40% of what flash has to offer

Very detailed manual but really meant for the professional. Not what I was looking for. But a terrific book for someone who really needs a detailed desk reference quality book for Flash CS6.

A fact filled manual designed to let you learn all the nuts and bolts of Flash CS6. Easy to read and understand. A treasure-trove of practical information and demonstrations. With this book you'll be a "Flash Pro" as quickly as you have time to assimilate all this information.Highly recommended for someone wanting a thorough knowledge of Flash CS6. For a quick start "How to Cheat" in Adobe Flash CS6 may be more in your line.

This is a very good source of information for Flash CS6, although the chapters are laid out a little bit oddle and seem to jump from topic to topic. I found this to be a more thorough discussion of the topics that the traditional classroom in a book series

Very enlightening. A lot of the information presented in Flash CS6 - The Missing Manual really needed to be included in their Classroom in a Book series. It's good to see they were clever enough to make sure the information gaps were filled with the Missing Manual series.

This is a great book for someone just starting to learn Flash. I got it for a required college course. I had some previous experience with Flash before taking the course with this book so there were times when the book didn't have enough in it for me, especially when it came to doing advanced ActionScript programming. But it's a perfect book if you want to get the basic down Flash and ActionScript.

This is a great resource for anyone interested in web design who is using the latest Adobe software, Dreamweaver CS6.

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